The Panthers began the 2007 season as playoff contenders, and won their opener against St. Louis Rams for the first time since 2003. However, the next week at home against the Houston Texans the Panthers jumped ahead 14-0 but lost 34-21. In week three, Jake Delhomme was lost for the season with an injured elbow, which resulted in Tommy John Surgery. The Panthers went on a five game losing streak, including a last-minute loss to the Atlanta Falcons.
The Panthers got their first home win in one calendar year, beating the San Francisco 49ers 31-14. Following a 37-6 loss to the Jacksonville Jaguars, John Fox started undrafted free agent rookie Matt Moore who led the Carolina Panthers to a 13-10 win over the Seattle Seahawks at home. The Panthers finished 7-9, missing the playoffs for the second straight season. Matt Moore was 2-1 as a starter. Julius Peppers had a career low in sacks. Jon Beason, rookie, led the Carolina Panthers in tackles on defense. First year Panther strong safety Chris Harris led the NFL in forced fumbles.

